Life can really burn you. Any time. Any age. Literally! For example, you can be out in the sun for only a couple hours in the afternoon. Then later you hit the sack, wake up red and burned, and hurt because of the effects of the sun’s rays. And yet: - You thought getting a little tan the day before would have protected you from burning. What happened? - You applied sunscreen early in the morning that was supposed to last all day long. What went wrong? - You can’t remember what to do for sunburns. Should you apply butter to the area? Well, read on. We’ll help you get answers to these questions and many more.
Get a healthy-looking glow with this safe alternative to tanning. This light, non-sticky foam glides on smoothly to apply easily and evenly. Absorbs quickly and dries in less than 5 minutes. Patented foam formula provides a completely natural-looking tan that looks like a real tan and fades like a real tan – not orange, not streaky.
This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: Dihydroxyacetone (DHA), the active substance in sunless tanning lotions reacts with the amino groups of proteins to form a brown-colored complex. This non-enzymatic glycation, known as the Maillard reaction, can also occur with free amino groups in DNA, raising the possibility that DHA may be genotoxic. To address this issue we investigated the effects of DHA on cell survival and proliferation of a human keratinocyte cell line, HaCaT. Dose- and time-dependent morphological changes, chromatin condensation, cytoplasmic budding and cell detachment were seen in cells treated with DHA. Several dead cells were observed after long-time (24h) incubation with 25mM DHA or more. Furthermore, an extensive decline in proliferation was observed 1 day after DHA exposure for 24h. When applied in different concentrations (5-50mM) and for different time periods (1, 3 or 24h) DHA caused a G”2/M block after the cyclin B”1 restriction point. Exit from this cell-cycle block was associated with massive apoptosis, as revealed by a clonogenic assay, TUNEL staining and electron microscopy. Furthermore, DHA caused DNA damage as revealed by the alkaline comet assay. Preincubation with antioxidants prevented the formation of DNA strand breaks. The DHA toxicity may be caused by direct redox reactions, with formation of ROS as the crucial intermediates. The genotoxic capacity of DHA raises a question about the long-term clinical consequences of treatment of the skin with this commonly used compound.
This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description: Dihydroxyacetone (DHA), the active substance in sunless tanning lotions reacts with the amino groups of proteins to form a brown-colored complex. This non-enzymatic glycation, known as the Maillard reaction, can also occur with free amino groups in DNA, raising the possibility that DHA may be genotoxic. To address this issue we investigated the effects of DHA on cell survival and proliferation of a human keratinocyte cell line, HaCaT. Dose- and time-dependent morphological changes, chromatin condensation, cytoplasmic budding and cell detachment were seen in cells treated with DHA. Several dead cells were observed after long-time (24h) incubation with 25mM DHA or more. Furthermore, an extensive decline in proliferation was observed 1 day after DHA exposure for 24h. When applied in different concentrations (5-50mM) and for different time periods (1, 3 or 24h) DHA caused a G”2/M block after the cyclin B”1 restriction point. Exit from this cell-cycle block was associated with massive apoptosis, as revealed by a clonogenic assay, TUNEL staining and electron microscopy. Furthermore, DHA caused DNA damage as revealed by the alkaline comet assay. Preincubation with antioxidants prevented the formation of DNA strand breaks. The DHA toxicity may be caused by direct redox reactions, with formation of ROS as the crucial intermediates. The genotoxic capacity of DHA raises a question about the long-term clinical consequences of treatment of the skin with this commonly used compound.
Get a healthy-looking glow with this safe alternative to tanning. This light, non-sticky foam glides on smoothly to apply easily and evenly. Absorbs quickly and dries in less than 5 minutes. Patented foam formula provides a completely natural-looking tan that looks like a real tan and fades like a real tan – not orange, not streaky.
Build – 2 Patented delivery system ensures deep, even application with continuous hydration Build with the Best – Known, loved and trusted worldwide as the innovator of sunless tanning, Mystic Tan continues to deliver the perfect sunless results. The Mystic Tan system is designed with naturally-derived tanning agents and is enriched and antioxidant botanicals to create healthy-looking skin and the perfect tan. Designed to build the deepest, most natural-looking sunless tan. With our famous, patented, alcohol-free, quick-drying, deep penetrating tanning formulation used and trusted by millions each year. Creates smooth, even color. Combining the Mystic Tan formula with a continuous spray, micro-myst applicator. Easy to apply evenly at any angle. This 360 degree spray technology provides ease of use with even, controlled coverage – no rubbing required.
Life can really burn you. Any time. Any age. Literally! For example, you can be out in the sun for only a couple hours in the afternoon. Then later you hit the sack, wake up red and burned, and hurt because of the effects of the sun’s rays. And yet: - You thought getting a little tan the day before would have protected you from burning. What happened? - You applied sunscreen early in the morning that was supposed to last all day long. What went wrong? - You can’t remember what to do for sunburns. Should you apply butter to the area? Well, read on. We’ll help you get answers to these questions and many more.
Build – 2 Patented delivery system ensures deep, even application with continuous hydration Build with the Best – Known, loved and trusted worldwide as the innovator of sunless tanning, Mystic Tan continues to deliver the perfect sunless results. The Mystic Tan system is designed with naturally-derived tanning agents and is enriched and antioxidant botanicals to create healthy-looking skin and the perfect tan. Designed to build the deepest, most natural-looking sunless tan. With our famous, patented, alcohol-free, quick-drying, deep penetrating tanning formulation used and trusted by millions each year. Creates smooth, even color. Combining the Mystic Tan formula with a continuous spray, micro-myst applicator. Easy to apply evenly at any angle. This 360 degree spray technology provides ease of use with even, controlled coverage – no rubbing required.
Life can really burn you. Any time. Any age. Literally! 
This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Build – 2